Journal article
Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations
MI Garrido, GR Barnes, D Kumaran, EA Maguire, RJ Dolan
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
Abstract
Detecting environmental change is fundamental for adaptive behavior in an uncertain world. Previous work indicates the hippocampus supports the generation of novelty signals via implementation of a match-mismatch detector that signals when an incoming sensory input violates expectations based on past experience. While existing work has emphasized the particular contribution of the hippocampus, here we ask which other brain structures also contribute to match-mismatch detection. Furthermore, we leverage the fine-grained temporal resolution of magnetoencephalography (MEG) to investigate whether mismatch computations are spectrally confined to the theta range, based on the prominence of this ra..
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Awarded by Centre of Excellence for Integrative Brain Function, Australian Research Council
Funding Acknowledgements
This work was funded by an Australian Research Council Discovery Early Career Researcher Award (DE130101393) and the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007) to MIG; a Wellcome Trust Project Grant (085316/Z/08/Z) to RJD; an MRC UK MEG Partnership Grant (MR/K005464/1) to GRB; a Wellcome Trust Fellowship to DK (WT085189MA), and a Wellcome Trust Principal Research Fellowship (101759/Z/13/Z) to EAM. We thank Heidi Bonnici and Will Penny for discussions; David Bradbury, Letitia Manyande, and Janice Glensman for help with data collection; and the volunteers for participating in this study.